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Related Experiment Video

Updated: Jun 24, 2026

Rapid Generation of Amyloid from Native Proteins In vitro

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Autonomic failure in primary amyloidosis.

Aditi Pandit¹, Savita Gangurde, S B Gupta

¹Medicine and Cardiology, Bharat Ratna Dr. Babasaheb Ambedkar Memorial Hospital, Central Railway, Byculla, Mumbai.

The Journal of the Association of Physicians of India

|March 28, 2009

Summary

Primary Amyloidosis, a rare plasma cell disorder, typically affects multiple systems. This case highlights a unique presentation of pure autonomic failure without peripheral nerve involvement, challenging existing documentation.

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Area of Science:

Neurology
Hematology
Pathology

Background:

Amyloidosis is a rare plasma cell dyscrasia characterized by extracellular amyloid protein deposition in tissues.
Primary Amyloidosis affects multiple systems, with peripheral nerve involvement occurring in 20% of cases.
Polyneuropathy is a common manifestation, but pure autonomic failure without nerve involvement is undocumented.

Observation:

A case of Primary Amyloidosis presented with symptoms solely of autonomic dysfunction.
The patient exhibited pure autonomic failure (dysautonomia).
Peripheral nerve examination did not reveal significant neuropathy.

Findings:

This case represents a novel presentation of Primary Amyloidosis.
Pure autonomic failure is identified as a potential, albeit rare, manifestation of Primary Amyloidosis.
The findings expand the clinical spectrum of this multisystem disorder.

Implications:

Clinicians should consider Primary Amyloidosis in cases of unexplained pure autonomic failure.
Further research is needed to understand the mechanisms underlying this presentation.
This case may prompt re-evaluation of diagnostic criteria and clinical suspicion for amyloidosis.