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Related Experiment Video

Updated: Jun 24, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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Cryoglobulinemia presenting as acute polyneuropathy.

D Kishore1, S Misra

  • 1Department of Neurology, Institute of Medical Sciences, B.H.U, Varanasi, India.

The Journal of the Association of Physicians of India
|March 28, 2009
PubMed
Summary

This study reports a case of acute axonal neuropathy and palpable purpura in a 48-year-old male. Nerve biopsy confirmed myelinated fibre loss and necrotizing vasculitis, suggesting an autoimmune basis for the condition.

Area of Science:

  • Neurology
  • Rheumatology
  • Pathology

Background:

  • A 48-year-old male presented with acute axonal neuropathy.
  • The patient also exhibited palpable purpura on bilateral lower limbs.

Observation:

  • Serum analysis revealed the presence of Rheumatoid Factor (RA factor) and cryoglobulins.
  • Nerve biopsy was performed to investigate the neuropathy.

Findings:

  • Histopathological examination of the nerve biopsy showed significant myelinated fibre loss and axonal degeneration.
  • The biopsy also identified necrotizing vasculitis affecting the epineural blood vessels.

Implications:

  • These findings suggest a link between systemic autoimmune processes, such as those indicated by RA factor and cryoglobulins, and the development of peripheral neuropathy.

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  • The necrotizing vasculitis observed in the nerve biopsy highlights a potential mechanism for nerve damage in this patient.
  • This case underscores the importance of considering vasculitis in the differential diagnosis of acute axonal neuropathies presenting with purpura.