Related Experiment Video
Updated: Jun 24, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Release behavior of amoxicillin from glycol chitosan superporous hydrogels
1Department of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University, Suwon, Kyunggi 440-746, South Korea.
Abstract:
Two kinds of amoxicillin-containing glycol chitosan superporous hydrogels, drug-dispersed and drug-conjugated, were synthesized as candidates for an efficient drug-delivery system to eradicate Helicobacter pylori. The swelling and drug-release patterns were investigated for application as drug carriers to cure gastric disease. Both the swelling capacity and swelling kinetics decreased with decreasing network mesh size associated with increasing cross-linking density. The drug-conjugated system showed much slower drug-release patterns than the drug-dispersed system, thus prolonging the drug-delivery effect. This difference in drug-release kinetics is attributed to the difference in the main release mechanism, diffusion for the drug-dispersed and hydrolysis for the drug-conjugated system.
More Related Videos
05:26Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
15:33Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Related Concept Videos
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Rate-Programmed II
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention