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Related Concept Videos

Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

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Related Experiment Video

Updated: Jun 24, 2026

Robot Assisted Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer: Surgical Planning and Technique
13:56

Robot Assisted Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer: Surgical Planning and Technique

Published on: August 14, 2021

Coagulation function in patients with pancreatic carcinoma.

Hang-Yan Wang1, Dian-Rong Xiu, Zhi-Fei Li

  • 1Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Chinese Medical Journal
|March 28, 2009
PubMed
Summary

Elevated fibrinogen levels are observed in pancreatic carcinoma patients, potentially linked to cancer invasiveness and metastasis. Vitamin K did not impact intraoperative blood loss in this patient group.

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An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

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Last Updated: Jun 24, 2026

Robot Assisted Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer: Surgical Planning and Technique
13:56

Robot Assisted Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer: Surgical Planning and Technique

Published on: August 14, 2021

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Area of Science:

  • Oncology
  • Hematology
  • Surgical Pathology

Background:

  • Coagulation function abnormalities are noted in pancreatic carcinoma, but underlying reasons remain unclear.
  • This study retrospectively investigates coagulation parameters in patients diagnosed with pancreatic cancer.

Purpose of the Study:

  • To analyze coagulation function in patients with pancreatic carcinoma.
  • To identify potential associations between coagulation parameters and clinical factors like jaundice, invasiveness, and metastasis.

Main Methods:

  • Retrospective analysis of 132 pancreatic carcinoma patients diagnosed between June 2004 and December 2007.
  • Collected and studied coagulative parameters: prothrombin time, activated partial thromboplastin time, and fibrinogen levels.
  • Compared fibrinogen levels between pancreatic carcinoma patients and cholangiolithiasis patients, and within pancreatic carcinoma subgroups based on clinical characteristics.

Main Results:

  • Pancreatic carcinoma patients exhibited significantly higher average fibrinogen levels (476.21 ± 142.05 mg/dl) compared to cholangiolithiasis patients (403.28 ± 126.41 mg/dl).
  • Elevated fibrinogen levels correlated with jaundice, local invasiveness, and lymphatic metastasis in pancreatic carcinoma patients.
  • Perioperative vitamin K administration showed no significant difference in intraoperative blood loss.

Conclusions:

  • Fibrinogen levels are elevated in pancreatic carcinoma patients.
  • Elevated fibrinogen may correlate with tumor invasiveness and lymphatic spread.
  • Perioperative vitamin K does not appear to reduce intraoperative blood loss in this context.