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Stroke and Takotsubo cardiomyopathy: is there more than just cause and effect?

Will Lee, Konstantinos Profitis, Peter Barlis

    International Journal of Cardiology
    |March 28, 2009
    PubMed

    Insights

    Takotsubo cardiomyopathy, a stress-induced heart condition, can occur alongside stroke. This case suggests a potential shared cause, possibly related to catecholamine excess, linking cardiac and neurological events.

    Area of Science:

    • Cardiology
    • Neurology
    • Pathophysiology

    Background:

    • Takotsubo cardiomyopathy is often linked to cerebrovascular events.
    • The exact relationship and underlying mechanisms between Takotsubo cardiomyopathy and stroke remain under investigation.

    Observation:

    • A 43-year-old woman experienced Takotsubo cardiomyopathy followed by a large cerebellar infarct.
    • No clear cardioembolic source or significant neurological deficits were identified for the stroke.

    Findings:

    • The concurrent presentation of Takotsubo cardiomyopathy and stroke suggests a potential unifying pathogenetic mechanism.
    • Catecholamine excess is a proposed factor contributing to both myocardial stunning in Takotsubo cardiomyopathy and cerebral ischemia.

    Implications:

    • This case highlights a possible shared etiology between Takotsubo cardiomyopathy and stroke.
    • Further research into the role of catecholamines may elucidate the connection between these seemingly disparate conditions.

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