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Updated: Jun 24, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
Published on: March 7, 2018
Scaling properties of transcription profiles in gene networks
Renata C Ferreira1, Francisco Bosco, Marcelo R S Briones
1Departamento de Microbiologia, Imunologia e Parasitologia, Federal University of Sao Paulo, Ed. Ciencias Biomedicas, Rua Botucatu, 862 Sao Paulo, SP 04023-062, Brazil. renata.carmona@unifesp.br
Abstract:
Here we show that the transcriptional noise is an emergent property with scale invariance from genome level to the level of small Transcriptional Regulatory Genetic Networks (TRGN). We show that a small set of 9-12 genes reproduces the geometric mean value of transcriptional noise of the largest percolating networks and the whole 93-gene wide TRGN sub-network. Our results predict that the collapse of the standard deviation of the transcriptional noise as a function of gene sub-networks connectivity should occur for 1000 genes, the approximate size of the maximal interconnected percolating network cluster, which corresponds to the minimal genome size.
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