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Updated: Jun 24, 2026
08:45
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
Intravenous iron sucrose changes the intraperitoneal homeostasis.
A Breborowicz1, A Połubinska, M Kupczyk
1Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland. abreb@ump.edu.pl
Blood Purification
|March 28, 2009
Summary
Intravenous iron sucrose infusion in peritoneal dialysis patients increases oxidative stress and inflammation in peritoneal cells. This may negatively impact the long-term viability of the peritoneum.
Area of Science:
- Nephrology
- Cell Biology
- Biochemistry
Background:
- Intravenous iron sucrose (IS) is standard for uremic patients.
- Its effect on intraperitoneal homeostasis in peritoneal dialysis (PD) patients is unclear.
Purpose of the Study:
- To evaluate the impact of intravenous IS infusion on intraperitoneal homeostasis in PD patients.
Main Methods:
- 10 PD patients received intravenous IS.
- Blood and dialysate samples analyzed for iron, oxidative stress markers (8-OHdG), and cell counts.
- Peritoneal permeability and transperitoneal transport assessed.
- In vitro studies on human peritoneal mesothelial cells (MCs) exposed to spent dialysate.
Main Results:
- IS infusion increased dialysate iron and plasma/dialysate 8-OHdG.
- Transiently decreased peritoneal permeability to protein and glucose.
- Increased dialysate hyaluronan.
- Spent dialysate induced oxidative stress, reduced MC proliferation, and increased MCP-1 synthesis in vitro.
- Increased iron content in MCs.
Conclusions:
- Intravenous IS infusion induces oxidative stress and inflammation in peritoneal MCs.
- This may compromise peritoneal membrane viability in PD patients.
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