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Updated: Jun 24, 2026
In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
Published on: April 13, 2014
Methodology to obtain a mixed sural nerve recording in mice
Mayisha W Dunham1, Sarah E James, Teresa E Lever
1Department of Physical Medicine and Rehabilitation, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA.
Objective:
There is an increasing interest in using mouse models for electrodiagnostic research. Studying transgenic mice with various pathologies adds to our knowledge of the natural history of a disease. It is imperative, however, to compare disease models with the appropriate control.
Design:
For these animals to be used in electrodiagnostic research, reference values must be set. If reference values are not available, the validity of data are highly questionable. We propose a method of obtaining mixed nerve action potentials and collect reference values from the sural nerve of mice.
Results:
The results were a mean peak latency of 1.74 msecs on the right and 1.89 msecs on the left. The mean amplitude was 17.0 microV on the left and 21.6 microV on the right.
Conclusions:
In future studies, these reference values can be useful tools in analysis of murine subjects.
