Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 24, 2026

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

Biomedical discovery acceleration, with applications to craniofacial development.

Sonia M Leach1, Hannah Tipney, Weiguo Feng

  • 1Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, USA.

Plos Computational Biology
|March 28, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating and brain-resident memory CD8+ T cells seed distinct bystander T <sub>RM</sub> -like populations in glioblastoma.

bioRxiv : the preprint server for biology·2026
Same author

Metabolic alterations in cystic fibrosis lymphocyte memory accompanies restoration of CFTR function.

American journal of respiratory cell and molecular biology·2026
Same author

Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression.

BMJ open·2026
Same author

The future of fundamental science led by generative closed-loop artificial intelligence.

Frontiers in artificial intelligence·2026
Same author

Direct and Indirect Effects of a Glyphosate-Based Herbicide on Spodoptera frugiperda Multiple Nucleopolyhedrovirus (<i>Baculoviridae</i>) on Diet, Maize Plants and Soil.

Insects·2026
Same author

Invertebrate Iridescent Viruses (<i>Iridoviridae</i>) from the Fall Armyworm, <i>Spodoptera frugiperda</i>.

Viruses·2026

A new computational tool, Hanalyzer, aids researchers in analyzing complex biomedical data. It integrates information from diverse sources to generate testable hypotheses, accelerating scientific discovery in fields like craniofacial development.

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Molecular Biomedicine

Background:

  • High-throughput instruments generate vast scientific data, challenging researchers.
  • Existing computational tools may not adequately address the complexity of integrating diverse data sources.

Purpose of the Study:

  • To introduce a novel knowledge-based computational system for analyzing experimental data.
  • To facilitate the navigation and interpretation of extensive scientific literature and datasets.

Main Methods:

  • Developed a system combining reading (information extraction), reasoning (knowledge enrichment and network construction), and reporting (visualization).
  • Utilized natural language processing and structured data parsing for information retrieval.
  • Constructed a knowledge network with reliability scores and integrated it with experimental data networks.

More Related Videos

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
02:42

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography

Published on: January 17, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Related Experiment Videos

Last Updated: Jun 24, 2026

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
02:42

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography

Published on: January 17, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Main Results:

  • Implemented the system as the Hanalyzer tool.
  • Applied Hanalyzer to a large-scale gene expression dataset for craniofacial development.
  • Generated novel hypotheses on four previously uncharacterized genes in craniofacial development.

Conclusions:

  • The Hanalyzer tool is effective in knowledge-based data analysis.
  • Validated hypotheses underscore the tool's utility in identifying new gene functions.
  • This approach aids researchers in making sense of complex biological data and generating new research directions.