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Updated: Jun 24, 2026

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Published on: February 21, 2021

Myeloid/NK cell acute leukemia.

Bobin Chen¹, Xiaoping Xu², Meirong Ji¹

¹Department of Hematology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Urumuqi Road (Middle), 200040, Shanghai, People's Republic of China.

International Journal of Hematology

|March 28, 2009

Summary

Myeloid/NK cell leukemia is a distinct, mature entity differing from precursor acute leukemia. This case study details its presentation, immunophenotype, and successful treatment with acute myeloid leukemia chemotherapy.

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Area of Science:

Hematology
Oncology
Immunology

Background:

Myeloid/NK cell leukemia represents a distinct hematologic malignancy.
It is characterized by more mature cells compared to precursor acute leukemia or blastic NK cell lymphoma/leukemia.

Observation:

A patient presented with leukocytosis, anemia, and thrombocytopenia.
Bone marrow morphology resembled acute promyelocytic leukemia.
Leukemia cells expressed CD13, CD33, CD15, and CD56, but lacked CD34, HLA-DR, and CD16.

Findings:

The case exhibited a unique immunophenotype without abnormal cytogenetics.
The patient achieved complete remission following treatment.
Treatment followed standard protocols for acute myeloid leukemia.

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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

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Last Updated: Jun 24, 2026

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

Published on: February 21, 2021

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Implications:

This case highlights the distinct nature of Myeloid/NK cell leukemia.
Standard chemotherapy for acute myeloid leukemia can be effective.
Further research into this specific leukemia subtype is warranted.