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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

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Related Experiment Video

Updated: Jun 24, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

Identifying responsive functional modules from protein-protein interaction network.

Zikai Wu1, Xingming Zhao, Luonan Chen

  • 1Institute of Systems Biology, Shanghai University, Shanghai 200444, China.

Molecules and Cells
|March 28, 2009
PubMed
Summary
This summary is machine-generated.

Identifying responsive functional modules from protein interaction data is crucial for understanding cellular systems. This review covers computational methods for extracting these modules, essential for systems biology research.

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Area of Science:

  • Systems Biology
  • Computational Biology
  • Bioinformatics

Background:

  • Cellular functions arise from dynamic protein interactions, which are often condition-specific.
  • High-throughput data provides extensive protein interaction information but requires condition-specific analysis.
  • Understanding condition-dependent interactions is key to deciphering biological processes and phenotypes.

Purpose of the Study:

  • To review recent advances in computational methods for extracting responsive functional modules and active pathways.
  • To discuss the challenges and future directions in identifying condition-specific protein interaction networks.

Main Methods:

  • Analysis of protein interaction networks and microarray data.
  • Formulation of responsive functional module identification as an optimization problem.
  • Review of computational algorithms for extracting condition-specific biological networks.

Main Results:

  • Recent computational methods enable the extraction of condition-specific protein interaction modules.
  • These methods are vital for identifying signaling pathways and biological mechanisms.
  • Responsive functional modules can aid in discovering biomarkers for diseases.

Conclusions:

  • Efficient computational approaches are necessary for tackling the NP-hard problem of extracting responsive functional modules.
  • Further research is needed to overcome existing obstacles in computational network biology.
  • This field holds significant promise for advancing systems biology and understanding complex diseases.