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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Sarcoid-like granulomas in common variable immunodeficiency.

Hasibe Artac1, Banu Bozkurt, Beril Talim

  • 1Department of Pediatrics, Division of Immunology and Allergy, Selcuk University Meram Medical Faculty, Konya, Turkey. hasibeartac@yahoo.com

Rheumatology International
|March 28, 2009
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) in children can manifest with autoimmune conditions like granulomas, uveitis, and arthritis. Early diagnosis and multidisciplinary care are crucial for managing these complex autoimmune presentations.

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Area of Science:

  • Immunology
  • Pediatrics
  • Rheumatology

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia and impaired antibody production.
  • Patients with CVID exhibit an increased risk of autoimmune diseases and granulomatous complications affecting various organs.

Observation:

  • A 5-year-old girl with CVID presented with a rare combination of cutaneous nodules, granulomatous uveitis, and oligoarthritis.
  • These clinical manifestations suggest a significant overlap between immunodeficiency and autoimmune/granulomatous processes.

Findings:

  • The patient's symptoms, including skin lesions, arthritis, and uveitis, showed a positive response to systemic corticosteroid therapy.
  • This case highlights the potential for multiple autoimmune and granulomatous conditions to co-occur in pediatric CVID.

Implications:

  • Children with CVID may present with diverse and concurrent autoimmune manifestations requiring specialized medical attention.
  • Effective management necessitates collaborative efforts between immunologists, dermatologists, rheumatologists, and ophthalmologists for comprehensive patient care.