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Updated: Jun 24, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Development of a computer program for permeation testing data analysis.

Pengfei Gao¹, Tyson Weise, Beth Tomasovic

¹National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania 15236, USA. PGao@cdc.gov

Journal of Occupational and Environmental Hygiene

|March 28, 2009

Summary

This summary is machine-generated.

A new Permeation Calculator software from NIOSH automates analysis of permeation testing data. This tool standardizes results, preventing bias and saving time for industrial hygienists and researchers analyzing protective material performance.

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Area of Science:

Occupational Safety and Health
Materials Science
Chemical Engineering

Background:

Permeation testing is crucial for evaluating protective materials against chemical exposure.
Manual analysis of permeation data is time-consuming, prone to errors, and can introduce experimenter bias.
Standardized methods like ASTM F 739, ISO 6529, and ASTM D 6978 are essential for reliable results.

Purpose of the Study:

To develop and introduce the Permeation Calculator software for automated and standardized analysis of permeation testing data.
To provide a tool that accurately calculates key permeation parameters according to international standards.
To eliminate manual calculations and reduce potential bias in permeation data analysis.

Main Methods:

Development of a Microsoft Windows-compatible software program named 'Permeation Calculator'.
Implementation of algorithms, strategies, and automated decision-making processes for data analysis.
Importing permeation test data files and calculating parameters including breakthrough times, permeation rates, and cumulative mass.

Main Results:

The software calculates all required permeation parameters for closed-loop and open-loop tests under ASTM F 739, ISO 6529, and ASTM D 6978 standards.
Calculations are performed rapidly (within seconds) and results are presented in Microsoft Excel and text file formats.
The software supports open-loop testing with flowrate adjustments and calculates average and maximum permeation rates.

Conclusions:

The Permeation Calculator software effectively automates and standardizes permeation testing data analysis.
It enhances accuracy, reduces labor, and prevents bias, ensuring consistent results for industrial hygienists and researchers.
The software is readily available from the NIOSH website or via CD request.