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Published on: March 8, 2024

Carboline alkaloids from Trigonostemon lii.

Xu-Jia Hu1, Ying-Tong Di, Yue-Hu Wang

  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.

Planta Medica
|March 28, 2009
PubMed
Summary

Six new beta-carboline alkaloids, trigonostemonines A-F, were identified in Trigonostemon lii. Trigonostemonine F demonstrated moderate cytotoxic activity against HL-60 cancer cells.

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Medicinal Chemistry

Background:

  • Trigonostemon lii is a plant species with potential for novel chemical compound discovery.
  • Beta-carboline alkaloids are a class of natural products with diverse biological activities.
  • Previous research has not reported beta-carboline alkaloids in the Trigonostemon genus.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from Trigonostemon lii.
  • To investigate the presence of beta-carboline alkaloids in Trigonostemon species for the first time.
  • To evaluate the cytotoxic activity of the isolated compounds.

Main Methods:

  • Extraction of alkaloids from the roots and stems of Trigonostemon lii.
  • Structure elucidation of isolated compounds using spectroscopic analyses (e.g., NMR, MS).
  • Cytotoxicity assays against the HL-60 cell line to determine IC50 values.

Main Results:

  • Six new beta-carboline alkaloids, named trigonostemonines A-F (1-6), were successfully isolated.
  • The chemical structures of these novel compounds were determined through comprehensive spectroscopic data.
  • Trigonostemonine F exhibited moderate cytotoxic activity against HL-60 cells with an IC50 of 16 microM.

Conclusions:

  • This study reports, for the first time, the isolation of beta-carboline alkaloids from Trigonostemon species.
  • The discovery of trigonostemonines A-F expands the known chemical diversity within this alkaloid class.
  • Trigonostemonine F shows potential as a cytotoxic agent warranting further investigation.