Related Experiment Video

Updated: Jun 24, 2026

Isolation of Atrial Myocytes from Adult Mice
08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass

Amanda A Fox1, Charles D Collard, Stanton K Shernan

  • 1Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. afox@partners.org

Anesthesiology
|March 28, 2009
PubMed

Insights

Genetic variants in NPPA/NPPB and NPR3 genes influence the risk of ventricular dysfunction after coronary artery bypass grafting. This finding may improve understanding of postoperative ventricular dysfunction mechanisms.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Surgical Outcomes

Background:

  • Postoperative ventricular dysfunction (VnD) after coronary artery bypass grafting (CABG) increases morbidity and mortality.
  • Natriuretic peptides play a role in managing myocardial stress and failure.
  • Genetic variations in the natriuretic peptide system may predict VnD risk.

Purpose of the Study:

  • To investigate whether natriuretic peptide system gene variants independently predict the risk of VnD after primary CABG.
  • To identify specific genetic markers associated with postoperative ventricular dysfunction.

Main Methods:

  • Prospective enrollment of 1,164 patients undergoing primary CABG.
  • Analysis of 697 patients of European descent, with VnD defined by inotropic support or mechanical support.
  • Genotyping of 139 single nucleotide polymorphisms (SNPs) in 7 genes related to the natriuretic peptide system.

Main Results:

  • Seven NPPA/NPPB SNPs were associated with a decreased risk of postoperative VnD (odds ratios 0.44-0.55).
  • Four NPR3 SNPs were associated with an increased risk of postoperative VnD (odds ratios 3.89-4.28).
  • Associations were adjusted for clinical covariates and multiple comparisons.

Conclusions:

  • Genetic variations in NPPA/NPPB and NPR3 genes are linked to the risk of VnD following CABG.
  • Identifying these genotypic predictors can enhance the understanding of molecular mechanisms behind postoperative VnD.
Abstract

More Related Videos

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...