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Published on: January 28, 2019

Concomitant rotavirus and Salmonella infections in children with acute diarrhea

Wen-Tzong Lan1, Hung-Chang Lee, Chun-Yan Yeung

  • 1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

Pediatrics and Neonatology
|March 31, 2009
PubMed

Insights

Concomitant rotavirus and Salmonella infections in children present with distinct symptoms, including more vomiting and prolonged high fever. These dual infections are associated with higher C-reactive protein (CRP) levels and increased hypokalemia incidence.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • The incidence of rotavirus and Salmonella co-infection ranges from 1.3% to 7.4%.
  • Understanding clinical differences is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To compare clinical manifestations in children with rotavirus, Salmonella, or both infections.
  • To identify specific indicators of dual rotavirus and Salmonella gastroenteritis.

Main Methods:

  • Retrospective review of medical records for children with rotavirus or Salmonella gastroenteritis in 2001.
  • Categorization into rotavirus (R), Salmonella (S), and concomitant (C) groups.
  • Statistical analysis using chi-squared, ANOVA, Bonferroni, Kruskal-Wallis tests, and odds ratios.

Main Results:

  • Concomitant infections (Group C) occurred in 3.7% of 895 cases.
  • Group C showed more vomiting than Group S (p=0.0017).
  • Group C had prolonged high fever (>39°C), green stools with mucus/blood (p<0.001), higher CRP (9.70±11.05 mg/dL), and more hypokalemia (30.0%) compared to single infections.

Conclusions:

  • Concomitant rotavirus and Salmonella infections present with unique clinical and laboratory findings.
  • Elevated CRP and hypokalemia are significant indicators of dual infection.
  • Consider co-infection in rotavirus gastroenteritis cases with persistent high fever and bloody, mucoid, green stools.
Abstract

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