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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Jun 24, 2026

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

Kaposiform hemangioendothelioma.

Y Fernández1, M Bernabeu-Wittel, J S García-Morillo

  • 1Medical Oncology Department, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain. yfernandezdiez@yahoo.es

European Journal of Internal Medicine
|March 31, 2009
PubMed
Summary

Kaposiform hemangioendothelioma (KHE) is a rare childhood vascular tumor. Early suspicion of KHE is crucial, especially with consumptive coagulopathy, to guide diagnosis and treatment for better patient outcomes.

Area of Science:

  • Vascular Neoplasms
  • Pediatric Oncology
  • Dermatology

Background:

  • Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular neoplasm primarily affecting children.
  • KHE typically presents as skin masses with infiltrative growth, often associated with Kasabach-Merritt syndrome and lymphangiomatosis.
  • While visceral involvement is uncommon, KHE can occur in adults, though rarely.

Purpose of the Study:

  • To summarize the key characteristics, clinical presentation, and prognostic factors of Kaposiform hemangioendothelioma.
  • To highlight the importance of recognizing KHE in the differential diagnosis of vascular tumors, particularly when associated with coagulopathy.
  • To discuss the challenges in managing KHE and factors influencing patient outcomes.

Main Methods:

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  • Review of existing literature on Kaposiform hemangioendothelioma.
  • Analysis of clinical features, diagnostic criteria, and treatment responses reported in KHE cases.
  • Synthesis of information regarding prognostic indicators and mortality rates associated with KHE.

    • Main Results:

    • KHE is locally invasive but does not typically metastasize.
    • Factors influencing KHE outcomes include surgical accessibility, tumor location and size, and presence of associated syndromes.
    • High mortality rates (40-50%) are associated with large visceral KHE masses due to organ failure.

    Conclusions:

    • Consumptive coagulopathy in the presence of a vascular tumor warrants suspicion for KHE in both children and adults.
    • Prompt diagnosis and management considering prognostic factors are essential for improving outcomes in KHE.
    • Further research into effective therapeutic strategies for aggressive KHE is needed.