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Published on: August 1, 2025
Dendritic cell therapy in composite tissue allotransplantation
A W Thomson1, J M Sacks, Y-R Kuo
1Departments of Surgery and Immunology, Starzl Transplantation Institute and Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. thomsonaw@upmc.edu
Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.
Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.
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