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Updated: Jun 24, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
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Non-heart-beating donation: ethical aspects.

J L Vincent1, S Brimioulle

  • 1Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. jlvincen@ulb.ac.be

Transplantation Proceedings
|March 31, 2009
PubMed
Summary
This summary is machine-generated.

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Non-heart-beating donation (NHBD) involves ethical considerations. A two-step process is proposed, prioritizing patient beneficence and organ recipient benefit by optimizing organ quality through timely withdrawal of treatment.

Area of Science:

  • Medical Ethics
  • Transplantation Medicine
  • Organ Donation

Background:

  • Non-heart-beating donation (NHBD) faces ethical scrutiny regarding donor death determination and potential expedited withdrawal of treatment.
  • Concerns exist about the ethical implications of organ procurement before irreversible cessation of circulatory and respiratory functions.

Purpose of the Study:

  • To propose a two-step ethical framework for non-heart-beating donation (NHBD).
  • To address ethical debates surrounding NHBD by grounding the process in the principle of beneficence.
  • To optimize organ quality for recipients by ensuring timely organ procurement.

Main Methods:

  • The study suggests a sequential, two-step approach to NHBD.
  • The framework is based on the ethical principle of beneficence, focusing on patient well-being and recipient benefit.

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Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
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Last Updated: Jun 24, 2026

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  • It involves a decision-making process for withdrawal of treatment and subsequent organ procurement.

    • Main Results:

    • The proposed two-step process aims to resolve ethical dilemmas in NHBD.
    • The first step involves suggesting NHBD after determining no hope of survival and futility of treatment.
    • The second step advocates for rapid withdrawal of treatment to preserve optimal organ quality.

    Conclusions:

    • Implementing a structured two-step process for NHBD can mitigate ethical concerns.
    • Prioritizing beneficence ensures patient dignity and maximizes the benefit to organ recipients.
    • Timely organ procurement following treatment withdrawal is crucial for successful transplantation outcomes.