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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Related Experiment Video

Updated: Jun 24, 2026

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Anti-CD25 antibodies decrease the ability of human dendritic cells to prime allogeneic CD4 T cells.

K Mnasria1, C Lagaraine, F Velge-Roussel

  • 1JE 2448, Faculté de Médecine, Université François Rabelais, Tours, France.

Transplantation Proceedings
|March 31, 2009
PubMed
Summary
This summary is machine-generated.

Anti-CD25 monoclonal antibodies impact dendritic cell (DC) function, crucial for preventing transplant rejection. This study reveals anti-CD25 antibodies impair T-helper cell priming by DCs, offering new insights into their therapeutic mechanisms.

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Area of Science:

  • Immunology
  • Transplantation Biology
  • Cellular Immunology

Background:

  • Anti-CD25 monoclonal antibodies are vital for preventing acute allograft rejection in clinical transplantation.
  • While T lymphocyte effects are well-studied, the impact of these antibodies on human dendritic cells (DCs) and the role of interleukin-2 in DC function remain less understood.

Purpose of the Study:

  • To investigate the effects of anti-CD25 monoclonal antibodies on human dendritic cell (DC) function.
  • To elucidate the role of interleukin-2 in DC-mediated immune responses.

Main Methods:

  • Human monocyte-derived DCs were stimulated with lipopolysaccharide (LPS) or CD40L.
  • The expression of CD25 and co-stimulatory molecules was analyzed.
  • DC ability to prime T-helper cells was assessed after anti-CD25 antibody pretreatment.

Main Results:

  • LPS or CD40L stimulation strongly induced CD25 expression on DCs.
  • Pretreatment with anti-CD25 antibodies reduced the capacity of DCs to prime T-helper cells.
  • Humanized anti-CD25 antibodies did not inhibit the upregulation of key DC maturation markers (CD86, CD80, CD83, HLA-DR, CD40) induced by LPS.

Conclusions:

  • Anti-CD25 monoclonal antibodies exert previously unrecognized effects on dendritic cells.
  • These effects on DCs, particularly their T-helper cell priming ability, may contribute to the clinical efficacy of anti-CD25 therapies in transplantation.