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Updated: Jun 24, 2026
12:22
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Herpes simplex virus type 2 (Mollaret's) meningitis: a case report.
Mohammed Abu Khattab1, Hussam Al Soub, Mona Al Maslamani
1Department of Internal Medicine, Hamad Medical Corporation, PO Box 3050, Doha, Qatar. mabukhattab@gmail.com
Summary
Mollaret's meningitis, a recurrent aseptic meningitis, is often caused by herpes simplex virus. Early diagnosis and treatment with acyclovir can prevent prolonged illness and unnecessary treatments.
Area of Science:
- Neurology
- Infectious Diseases
Background:
- Mollaret's meningitis is a rare, recurrent aseptic meningitis syndrome.
- Herpes simplex virus type 2 (HSV-2) is the most common cause, followed by HSV-1.
Observation:
- A 49-year-old female experienced four episodes of recurrent lymphocytic meningitis over seven years.
- Diagnosis was confirmed as herpes simplex meningitis via PCR in cerebrospinal fluid during the fourth episode.
Findings:
- The patient received symptomatic treatment after diagnosis, with no further recurrences.
- Previous misdiagnoses led to unnecessary anti-tuberculous and antibiotic treatments.
Implications:
- Suspecting Mollaret's meningitis in recurrent lymphocytic meningitis is crucial for timely diagnosis.
- Early diagnosis can reduce hospital stays, investigations, and costs associated with misdiagnosis.
- Acyclovir treatment may shorten attack duration and prevent future episodes.
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