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A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study

Kazumasa Yamagishi1, Aaron R Folsom, Wayne D Rosamond

  • 1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454-1015, USA.

European Heart Journal
|March 31, 2009
PubMed

Insights

Genetic variations on chromosome 9p21, specifically the GG genotype of rs10757274, are linked to higher heart failure (HF) risk in white individuals. This 9p21 genetic marker also shows a weak association with carotid atherosclerosis.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • Polymorphisms on chromosome 9p21 are established risk factors for coronary heart disease (CHD).
  • Limited research has explored the association of these 9p21 polymorphisms with heart failure (HF), stroke, and subclinical atherosclerotic diseases.

Purpose of the Study:

  • To investigate the association between chromosome 9p21 polymorphisms and non-coronary atherosclerotic diseases.
  • To determine if 9p21 polymorphisms, known for CHD risk, are also associated with HF, stroke, and subclinical atherosclerosis.

Main Methods:

  • Analysis of 4018 African-American and 11 085 white participants from the Atherosclerosis Risk in Communities Study.
  • Examination of rs10757274 and rs2383206 polymorphisms in relation to incident HF, ischemic stroke, prevalent carotid atherosclerosis, and peripheral artery disease (PAD).

Main Results:

  • The GG genotype of rs10757274 was associated with increased HF risk in white participants, independent of known CHD links.
  • A weak association was observed between the GG genotype of rs10757274 and increased carotid atherosclerosis risk among whites.
  • No significant associations were found for ischemic stroke or PAD in relation to these polymorphisms.

Conclusions:

  • The GG genotype of rs10757274 on chromosome 9p21 is associated with increased heart failure risk in whites.
  • This genetic variant shows weak or no association with other major atherosclerosis outcomes like stroke and PAD.
Abstract

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