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A review of eGFR reporting after 6 months in practice
1Department of Clinical Biochemistry, Wirral University Teaching Hospital NHS Foundation Trust, Arrowe Park Hospital, Upton, UK.
Insights
Routine calculation of estimated glomerular filtration rate (eGFR) revealed a high prevalence of chronic kidney disease (CKD) stage 3 or higher. Age significantly impacts eGFR results, necessitating age-adjusted analysis for accurate CKD prevalence.
Area of Science:
- Nephrology
- Public Health
- Clinical Chemistry
Background:
- Routine calculation of estimated glomerular filtration rate (eGFR) from serum creatinine values in primary care revealed a high number of results indicating chronic kidney disease (CKD) stage 3 or higher.
- This observation prompted an investigation into the prevalence and potential contributing factors of these findings.
Purpose of the Study:
- To determine the prevalence of CKD stage 3 or higher based on eGFR values from primary care.
- To investigate the influence of demographic factors, particularly age, on the calculated eGFR results.
Main Methods:
- A retrospective review of 51,314 eGFR values from primary care samples collected between October 2006 and April 2007.
- Statistical analysis comparing the age distribution of individuals with eGFR indicating CKD stage 3+ to the general population.
Main Results:
- Over 25% of individuals had eGFR results consistent with CKD stage 3 or higher.
- The median age of this group (64 years) was significantly higher than the general population (40 years), indicating an age-related effect.
- After adjusting for age distribution, the estimated prevalence of CKD stage 3 was 5.6%, a higher figure than previously estimated.
Conclusions:
- The increased detection of CKD stage 3 is likely influenced by the age distribution of the studied population.
- Age is a significant factor affecting calculated eGFR values, highlighting the importance of age-specific interpretation.
- Routine eGFR calculation has increased the identified prevalence of chronic kidney disease.
Background:
Following the introduction of routine calculation of estimated glomerular filtration rate (eGFR) from all serum creatinine values in samples received from general practice it was noted that there was a preponderance of values consistent with chronic kidney disease (CKD) stage 3 or higher.
Methods:
A review was conducted of all eGFR values from 51 314 individuals received from primary care during October 2006 to April 2007.
Results:
It was found that more than 25% of eGFR results indicated CKD stage 3 or higher. The median age in this group was 64 years (range 18-104 years) while that of the local general population according to the 2001 census was 40 years (range 18-104 years); these ages were statistically significantly different (p<0.001). There was no difference between the groups with regard to gender. The eGFR data were therefore corrected for age distribution, and an estimated prevalence of 5.6% of eGFR consistent with CKD stage 3 was found. This was a higher proportion than estimates of CKD suggested before the introduction of eGFR.
Conclusions:
The higher proportion of CKD stage 3 may be due to difference in age and gender in populations studied, as there is a marked effect of age on calculated eGFR values found.
