Related Experiment Video

Updated: Jun 24, 2026

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

Clinical profile of Chikungunya in infants

Joseph J Valamparampil1, Shibi Chirakkarot, S Letha

  • 1Department of Pediatrics, Institute of Child Health, Government Medical College, Kerala, India.

Indian Journal of Pediatrics
|March 31, 2009
PubMed

Insights

Chikungunya infection in infants presents uniquely with fever, acrocyanosis, and distinct skin lesions, differing from older children. Close monitoring and rational treatment can prevent severe outcomes in infants.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Chikungunya virus (CHIKV) infection is a significant public health concern.
  • Clinical manifestations of CHIKV infection in infants are not well-defined.

Purpose of the Study:

  • To define the clinical manifestations of Chikungunya infection in infants.
  • To differentiate infant CHIKV presentation from older children.

Main Methods:

  • Prospective study of 56 infants (<1 year) with fever and specific clinical features.
  • Clinical examination, daily follow-up, and IgM antibody capture ELISA for CHIKV confirmation.
  • Serial order of clinical feature appearance documented.

Main Results:

  • Fever was universal; common symptoms included lethargy, irritability, and excessive cry.
  • Characteristic findings were acrocyanosis and superficial vesicobullous lesions.
  • Maculopapular rashes progressed to morbilliform, sparing the face and oral cavity.

Conclusions:

  • Infants exhibit a distinct clinical spectrum of Chikungunya compared to older children.
  • Vigilant monitoring and appropriate management are crucial to reduce infant morbidity and mortality.
  • Early recognition of unique infant symptoms aids in timely intervention.
Abstract

More Related Videos

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 106:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...