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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Related Experiment Video

Updated: Jun 24, 2026

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools
07:58

Quantifying Fibrillar Collagen Organization with Curvelet Transform-Based Tools

Published on: November 11, 2020

Is bone quality associated with collagen age?

D J Leeming1, K Henriksen, I Byrjalsen

  • 1Nordic Bioscience, Herlev Hovedgade 207, 2730, Herlev, Denmark. djl@nordicbioscience.com

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|March 31, 2009
PubMed
Summary

Osteoporosis fracture risk is influenced by more than just bone density. Measuring collagen changes in bone matrix provides insights into bone strength and fracture risk, independent of bone mineral density.

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Area of Science:

  • Biochemistry
  • Orthopedics
  • Gerontology

Background:

  • Osteoporosis is defined by decreased bone mass and microarchitectural deterioration, increasing fracture risk.
  • Emerging data indicate that factors beyond bone density, such as age and bone quality, significantly influence fracture risk.
  • Bone quality involves mineralization, microfractures, osteocyte apoptosis, and collagen properties, all regulated by bone remodeling.

Purpose of the Study:

  • To investigate the relationship between bone remodeling and collagen properties, specifically posttranslational modifications.
  • To assess the utility of a urinary collagen cross-link ratio as an indicator of bone matrix age and bone strength.

Main Methods:

  • In vivo measurement of the ratio between native and isomerized C-telopeptides of type I collagen.
  • Analysis of preclinical and clinical data correlating this ratio with bone strength and fracture risk.

Main Results:

  • The urinary collagen cross-link ratio serves as an index of bone matrix age.
  • This ratio provides information on bone strength and fracture risk independently of bone mineral density.
  • The ratio demonstrates differential responses to various bone turnover therapies.

Conclusions:

  • Bone matrix age, assessed via collagen cross-links, is a crucial factor in determining fracture risk.
  • This biomarker offers a novel approach to assessing bone health beyond traditional bone mineral density measurements.
  • Therapeutic interventions targeting bone turnover may alter collagen properties, impacting bone strength and fracture risk.