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Updated: Jun 24, 2026
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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
Published on: October 26, 2016
High-performance self-expanding stent graft: development and application to experimental aneurysms
Shogo Nishi1, Yasuhide Nakayama, Hatsue Ishibashi-Ueda
1Department of Neurosurgery, Interventional Neurosurgery, and Spinal Surgery, Sapporo Higashi-Tokushukai Hospital, 14-3-1 Higashi, Higashi-ku, Sapporo, Japan. nishi@higashi-tokushukai.or.jp
Summary
This study developed a novel stent graft for treating large craniocervical aneurysms. The new device effectively occluded experimental aneurysms in dogs, showing promise for future clinical applications.
Area of Science:
- Biomedical Engineering
- Vascular Surgery
- Interventional Radiology
Background:
- Large or giant aneurysms in the craniocervical area present significant treatment challenges due to broad necks.
- Current surgical and endovascular treatments carry relatively high risks.
Purpose of the Study:
- To develop and evaluate a high-performance stent graft for embolizing craniocervical aneurysms.
- To assess the efficacy of a novel stent graft in an experimental canine aneurysm model.
Main Methods:
- Fabrication of stent grafts using self-expanding stents covered with a segmented polyurethane (SPU) membrane.
- Incorporation of micropores via excimer laser ablation and an argatroban drug delivery system.
- Testing in experimental canine carotid artery aneurysms, comparing the novel stent graft to a bare stent.
Main Results:
- Complete occlusion of experimental aneurysms treated with the novel stent graft after 1 month.
- No significant parent artery stenosis observed in the treated arteries.
- Aneurysms treated with the bare stent remained open, indicating the novel graft's superior efficacy.
Conclusions:
- The developed high-performance stent graft is effective for complete aneurysm occlusion in a canine model.
- The stent graft demonstrated ease of application and promising results for clinical translation.
- Further research is warranted to support clinical use of this novel endovascular device.
