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Related Experiment Videos

Renal function after autologous bone marrow transplantation.

G Lönnerholm1, K Carlson, L E Bratteby

  • 1Dept. of Pediatrics, University Hospital, Uppsala, Sweden.

Bone Marrow Transplantation
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Autologous bone marrow transplantation (ABMT) can impair kidney function, with irradiation being a key risk factor for renal dysfunction. Close monitoring of renal function post-ABMT is crucial for patients, especially those receiving BEAC and TBI conditioning.

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • Autologous bone marrow transplantation (ABMT) is a critical treatment for hematologic and lymphoid malignancies.
  • Long-term effects of ABMT on renal function require thorough investigation.

Purpose of the Study:

  • To evaluate the long-term impact of ABMT on renal function in patients with hematologic and lymphoid malignancies.
  • To identify risk factors associated with renal dysfunction following ABMT.

Main Methods:

  • Retrospective analysis of 72 patients with relapse-free survival >6 months post-ABMT.
  • Assessment of glomerular filtration rate (GFR), serum creatinine, and serum urea levels.
  • Correlation of renal function with conditioning regimens, including total body irradiation (TBI) and BEAC chemotherapy.

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Main Results:

  • A significant decrease in mean GFR and increase in serum creatinine and urea were observed 6 months post-ABMT (p<0.01 and p<0.05, respectively).
  • 17% of patients developed renal dysfunction ( >25% GFR decrease), often with hematuria and proteinuria, 3-6 months post-ABMT.
  • Irradiation was the primary risk factor; the BEAC regimen combined with TBI showed a higher incidence of renal damage, suggesting potentiated toxicity.

Conclusions:

  • ABMT, particularly with irradiation, poses a risk of long-term renal dysfunction.
  • The combination of BEAC chemotherapy and TBI requires cautious use and warrants careful renal function monitoring.
  • Regular renal function assessment is essential for all patients undergoing ABMT to detect and manage treatment-related toxicities.