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Updated: Jun 24, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Composite lymphoma with relapse of enteropathy-type T-cell lymphoma
Zunguo Du1, Jieqing Chen, Xiaoyan Zhou
1Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
Abstract:
We describe an unusual case of with de novo composite diffuse large B-cell lymphoma and enteropathy-type T-cell lymphoma involving the duodenum in a 65-year-old man with celiac disease. A segmental duodenum resection revealed that two neoplastic components had infiltrated the intestinal wall. The coexistence of two malignancies was confirmed by immunohistochemical and molecular biologic analysis, which revealed clonal T-cell receptor gamma and immunoglobulin heavy chain gene rearrangements. Epstein-Barr virus was not detected in the B- and T-cell components. After chemotherapy, the patient experienced two relapses of enteropathy-type T-cell lymphoma only. We review the medical literature on composite B- and T-cell lymphomas and discuss their diagnosis, pathogenesis, prognosis and treatment.
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