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Related Experiment Video

Updated: Jun 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Mediastinal synovial sarcoma.

H Katakura¹, T Fukuse, I Shiraishi

¹Department of Thoracic Surgery, Kyoto University, Kyoto, Japan. katakura@otsu.jrc.or.jp

The Thoracic and Cardiovascular Surgeon

|March 31, 2009

Summary

This case report details a rare mediastinal synovial sarcoma. Despite surgical resection, the tumor recurred rapidly, leading to palliative care and patient death.

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Last Updated: Jun 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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Published on: October 2, 2015

Area of Science:

Oncology
Pathology

Background:

Mediastinal synovial sarcoma is a rare malignancy.
It presents diagnostic challenges due to overlapping features with other neoplasms.

Observation:

A case of synovial sarcoma located on the right pericardium is presented.
FDG-PET scan revealed tumor uptake.
Resection involved the pericardium and right middle lobe due to invasion.

Findings:

The tumor exhibited a rapid doubling time of 11.8 days.
Histological examination confirmed tumor-free margins post-resection.
Reverse transcription-PCR confirmed the synovial sarcoma diagnosis.

Implications:

This case highlights the aggressive nature of mediastinal synovial sarcoma.
Rapid recurrence post-surgery underscores the need for effective therapeutic strategies.
The patient's outcome emphasizes the challenges in managing this rare cancer.