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Mast cell stabilizing effects of Sphaeranthus indicus
Jessy E Mathew1, K K Srinivasan, Vachala Dinakaran
1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal 576 104, Karnataka, India. jessyjamesmathew@yahoo.co.in
Journal of Ethnopharmacology
|March 31, 2009
Summary
Sphaeranthus indicus extracts demonstrated potent mast cell stabilizing effects, significantly inhibiting mast cell degranulation. This research provides a scientific basis for the traditional use of S. indicus in managing inflammatory conditions.
Area of Science:
- Pharmacology
- Phytochemistry
- Immunology
Background:
- Mast cells play a crucial role in allergic and inflammatory responses.
- Mast cell degranulation leads to the release of mediators contributing to inflammation.
- Sphaeranthus indicus is a traditional medicinal plant with potential therapeutic applications.
Purpose of the Study:
- To investigate the mast cell stabilizing activity of Sphaeranthus indicus extracts.
- To provide scientific evidence supporting the clinical use of S. indicus.
Main Methods:
- Evaluation of the protective effects of various S. indicus extracts against compound 48/80 and sheep serum-induced mast cell degranulation.
- Comparison of extract efficacy with the standard drug ketotifen.
Main Results:
- Ethanol and ethyl acetate extracts of S. indicus exhibited significant mast cell stabilizing activity.
- Extracts showed superior protection against mast cell degranulation compared to ketotifen in both experimental models.
- Observed mast cell stabilization ranged from 77-88%.
Conclusions:
- Sphaeranthus indicus possesses potent mast cell stabilizing properties.
- The plant effectively inhibits the release of inflammatory mediators from mast cells.
- Findings support the pharmacological basis for S. indicus in managing mast cell-mediated disorders.
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