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Updated: Jun 24, 2026

Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
Efficient chemoenzymatic synthesis of chiral pincer ligands
Fulvia Felluga1, Walter Baratta, Lidia Fanfoni
1Dipartimento di Scienze Chimiche, Università di Trieste, via Giorgieri 1, I-34127 Trieste, Italy. ffelluga@units.it
Abstract:
Chiral, nonracemic pincer ligands based on the 6-phenyl-2-aminomethylpyridine and 2-aminomethylbenzo[h]quinoline scaffolds were obtained by a chemoenzymatic approach starting from 2-pyridyl and 2-benzoquinolyl ethanone. In the enantiodifferentiating step, secondary alcohols of opposite absolute configuration were obtained by a baker's yeast reduction of the ketones and by lipase-mediated dynamic kinetic resolution of the racemic alcohols. Their transformation into homochiral 1-methyl-1-heteroarylethanamines occurred without loss of optical purity, giving access to pincer ligands used in enantioselective catalysis.
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