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Related Experiment Videos

Lumbar nerve root compression and interstitial cystitis--response to decompressive surgery.

L Gillespie1, R Bray, N Levin

  • 1Division of Urology, University of California, Irvine.

British Journal of Urology
|October 1, 1991
PubMed
Summary
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Lumbar nerve root compression can cause urological dysfunction resembling interstitial cystitis. Surgical decompression of the L5 nerve root provided immediate pain relief in most patients, suggesting a novel treatment approach for chronic pelvic pain.

Area of Science:

  • Urology
  • Neurology
  • Pain Management

Background:

  • Chronic pelvic pain and urological dysfunction are often diagnosed as interstitial cystitis.
  • The etiology of interstitial cystitis remains incompletely understood, with various contributing factors proposed.

Purpose of the Study:

  • To investigate the potential link between lumbar nerve root compression and urological dysfunction consistent with interstitial cystitis.
  • To evaluate the efficacy of surgical decompression for L5 nerve root compression in patients with chronic pelvic pain and interstitial cystitis-like symptoms.

Main Methods:

  • Ten patients (9 female, 1 male) with chronic pelvic pain underwent evaluation.
  • Diagnostic methods included cystoscopy, histology, and magnetic resonance (MR) imaging of the lumbar spine.

Related Experiment Videos

  • Surgical decompression of the L5 dorsal nerve root foramina was performed on affected patients.

    • Main Results:

    • MR studies consistently revealed lateral compression of the L5 dorsal nerve root in all patients.
    • Cystoscopic and histological findings supported a diagnosis of interstitial cystitis.
    • Nine out of ten patients experienced immediate relief of pelvic pain following L5 nerve root decompression.
    • No recurrence of pain was observed during a 6-month follow-up period.

    Conclusions:

    • Lumbar nerve root compression, specifically at L5, may be an identifiable cause of urological dysfunction presenting as interstitial cystitis.
    • Surgical decompression of the L5 nerve root offers a promising and effective treatment for this specific patient group.
    • The findings suggest a potential role for sympathetic dystrophy of the pelvic plexus in the underlying pathophysiology.