Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GM-CSF downregulates type I IFN responses in glioblastoma-associated monocytes.

Experimental & molecular medicine·2026
Same author

Alox8 knockout exacerbates imiquimod-induced psoriasis-like inflammation.

Cell death & disease·2026
Same author

Co-administered internalizing RGD peptide boosts anti-PD-L1 therapy in hepatocellular carcinoma.

JHEP reports : innovation in hepatology·2026
Same author

Myeloid HIF1α has only a minor impact on atherosclerosis development.

Vascular biology (Bristol, England)·2026
Same author

Ferroptosis Enhances T Lymphocyte Infiltration into Glioblastoma Spheroids.

Antioxidants (Basel, Switzerland)·2025
Same author

Felix Hoppe-Seyler (1825-1895): a pioneer in the field of biochemistry with many significant contributions to the development of the discipline.

Biological chemistry·2025

Related Experiment Video

Updated: Jun 24, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

HIF-1 in the inflammatory microenvironment.

Nathalie Dehne1, Bernhard Brüne

  • 1Institute of Biochemistry I-Pathobiochemistry/ZAFES, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

Experimental Cell Research
|April 1, 2009
PubMed
Summary

Hypoxia-inducible factor (HIF) is crucial for both normal oxygen balance and disease, particularly in immune cells like macrophages. This review explores how HIF activation influences inflammation and immune cell function.

More Related Videos

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

Related Experiment Videos

Last Updated: Jun 24, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

Area of Science:

  • Immunology
  • Cellular Biology
  • Physiology

Background:

  • Hypoxia-inducible factor (HIF) is a key transcriptional activator regulating cellular responses to low oxygen conditions (hypoxia).
  • Increased HIF activity is observed in hypoxic/ischemic events and cancers, but HIF-1 is also vital for normal physiological processes like embryogenesis and energy metabolism.
  • Recent findings highlight HIF-1's role in maintaining oxygen homeostasis, extending its functions beyond pathological states to include immune system regulation.

Purpose of the Study:

  • To review the mechanisms of HIF activation in mammalian immune cells, focusing on macrophages and neutrophils.
  • To outline the role of HIF in moderating inflammatory processes.
  • To underscore the diverse, previously unappreciated functions of HIF in immune cell biology and O2 homeostasis.

Main Methods:

  • Literature review of studies on HIF activation in immune cells.
  • Analysis of research on HIF's role in macrophage and neutrophil biology.
  • Synthesis of findings on HIF's impact on inflammation and immune responses.

Main Results:

  • HIF activation is modulated by inflammatory microenvironments, affecting macrophage biology.
  • HIF plays a significant role in innate immune responses orchestrated by macrophages.
  • Multiple pathways adjust HIF-1alpha levels, influencing immune cell functions.

Conclusions:

  • HIF is essential for normal oxygen homeostasis and has critical functions in the immune system.
  • Understanding HIF activation in immune cells is key to comprehending inflammatory processes.
  • HIF's role in macrophages and neutrophils impacts their ability to manage inflammation and initiate resolution.