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Prevention of rotavirus disease: updated guidelines for use of rotavirus vaccine

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    Pediatrics
    |April 1, 2009
    PubMed

    Insights

    The American Academy of Pediatrics recommends routine rotavirus vaccination for infants using either the 3-dose RV5 (RotaTeq) or 2-dose RV1 (Rotarix) vaccine. Both vaccines are effective in preventing rotavirus gastroenteritis in infants.

    Area of Science:

    • Pediatrics
    • Vaccinology
    • Infectious Disease Prevention

    Background:

    • The 2007 American Academy of Pediatrics (AAP) statement on rotavirus gastroenteritis prevention is updated.
    • Two rotavirus vaccines, RV5 (RotaTeq) and RV1 (Rotarix), are licensed for infant use in the United States.

    Purpose of the Study:

    • To provide updated recommendations for the routine immunization of infants in the United States with rotavirus vaccine.
    • To outline the recommended schedules, contraindications, and precautions for rotavirus vaccine administration.

    Main Methods:

    • Review and synthesis of current evidence on rotavirus vaccines.
    • Formulation of updated clinical recommendations by the American Academy of Pediatrics.

    Main Results:

    • The AAP recommends routine rotavirus vaccination for all infants.
    • RV5 is a 3-dose series (2, 4, 6 months); RV1 is a 2-dose series (2, 4 months).
    • No preference is stated between RV5 and RV1.

    Conclusions:

    • Routine rotavirus immunization is recommended for all infants in the United States.
    • Specific age guidelines for vaccine administration (first dose 6-14.5 weeks, all doses by 8 months) are provided.
    • Guidance on contraindications, precautions, and special circumstances is included.

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