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Updated: Jun 24, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
High incidence of celiac disease in patients with systemic sclerosis
Edoardo Rosato1, Daniela De Nitto, Carmelina Rossi
1Department of Clinical Medicine, Clinical Immunology and Allergy Unit, La Sapienza University of Rome, Rome, Italy. edorosato@yahoo.com
Objective:
To evaluate the presence of celiac disease in patients with systemic sclerosis (SSc). The association of autoimmune diseases with celiac disease has been reported, but few publications deal with the combination of SSc and celiac disease.
Methods:
We investigated the presence of anti-tissue transglutaminase (anti-tTG) antibodies and serum antiendomysial antibodies (anti-EMA) in 50 patients with SSc. All subjects were on a gluten-containing diet. Duodenal mucosa histology and biopsy culture were performed in anti-tTG-positive patients; anti-EMA and IgA, IgG1 anti-tTG were detected in culture supernatants.
Results:
The incidence of celiac disease in patients with SSc was found to be 8%. Serum anti-tTG antibody-positive results were detectable in 5 out of 50 patients with SSc, but only in 4 of them was the diagnosis confirmed by histological results (Marsh classification).
Conclusion:
Our data show an increased prevalence of celiac disease in patients with SSc.
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