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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...

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Related Experiment Video

Updated: Jun 24, 2026

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Inflammatory arthritis: an overview for primary care physicians.

Lawrence H Brent1

  • 1Albert Einstein Medical Center, Einstein Arthritis Center, Philadelphia, PA 19141, USA. brentlh@hotmail.com

Postgraduate Medicine
|April 1, 2009
PubMed
Summary

Early diagnosis of inflammatory arthritis like rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) is crucial. This review helps primary care physicians (PCPs) identify and refer patients sooner to prevent joint damage.

Related Experiment Videos

Last Updated: Jun 24, 2026

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Area of Science:

  • Rheumatology
  • Primary Care Medicine

Background:

  • Advances in inflammatory arthritis treatment offer remission possibilities.
  • Delayed diagnosis and referral by primary care physicians (PCPs) hinder optimal patient outcomes.
  • Irreversible joint damage and functional compromise result from delayed interventions.

Purpose of the Study:

  • To assist PCPs in early recognition and referral of inflammatory arthritis.
  • To provide current criteria for disease activity, response, and remission in RA, AS, and PsA.
  • To discuss treatment options and interdisciplinary management.

Main Methods:

  • Review of current diagnostic and remission criteria for RA, AS, and PsA.
  • Discussion of traditional and biologic disease-modifying antirheumatic drugs (DMARDs).
  • Emphasis on the role of PCPs in early disease detection and management.

Main Results:

  • PCPs are pivotal in the initial recognition of inflammatory arthritis.
  • Clear diagnostic and remission criteria can expedite patient management.
  • Understanding treatment benefits and risks is essential for effective care.

Conclusions:

  • Early diagnosis and referral by PCPs are critical for managing inflammatory arthritis.
  • Adherence to established criteria improves patient outcomes.
  • Collaborative care across specialties enhances treatment efficacy.