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Related Experiment Video

Updated: Jun 24, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

MET pathway as a therapeutic target.

Eric S Kim¹, Ravi Salgia

¹Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA. rsalgia@medicine.bsd.uchicago.edu

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer

|April 1, 2009

Summary

Dysregulation of the mesenchymal-epithelial transition factor receptor tyrosine kinase pathway drives cancer progression. Targeting these pathways with new drugs shows promising results for cancer treatment.

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Last Updated: Jun 24, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

The mesenchymal-epithelial transition factor receptor tyrosine kinase pathway is crucial in cellular processes.
Dysregulation of this pathway contributes to cancer development and progression.

Purpose of the Study:

To summarize the role of the mesenchymal-epithelial transition factor receptor tyrosine kinase pathway in cancer.
To highlight mechanisms of pathway dysregulation.
To discuss emerging therapeutic strategies targeting this pathway.

Main Methods:

Literature review of studies on mesenchymal-epithelial transition factor receptor tyrosine kinase signaling.
Analysis of mechanisms driving pathway dysregulation.
Overview of current drug development targeting this pathway.

Main Results:

Pathway dysregulation promotes cell proliferation, apoptosis resistance, angiogenesis, invasion, and metastasis.
Mechanisms include overexpression, constitutive activation, gene amplification, ligand-dependent activation, and mutation.
Investigational drugs targeting this pathway demonstrate significant therapeutic potential.

Conclusions:

The mesenchymal-epithelial transition factor receptor tyrosine kinase pathway is a key driver of oncogenesis.
Understanding its dysregulation is vital for developing effective cancer therapies.
Targeted therapies offer a promising avenue for improved cancer treatment outcomes.