Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive

C Bakhit1, M Armanini, W L Wong

  • 1Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.

Brain Research
|July 19, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ruptured ovarian teratoma with granulomatous peritonitis.

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same author

Sudden cardiac arrest with pericardial contrast during computed tomography aortogram in a type A aortic dissection patient.

Hong Kong medical journal = Xianggang yi xue za zhi·2019
Same author

Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies.

Scientific reports·2018
Same author

Linkage disequilibrium among commonly genotyped SNP variants detected from bull sequence<sup></sup>.

Animal genetics·2017
Same author

Reducing the blame culture through clinical audit in nuclear medicine: a mixed methods study.

JRSM open·2017
Same author

Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study.

BMJ open respiratory research·2016
Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026
Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026
Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026
Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026
Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026
Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026
See all related articles

Mild spinal cord injury in rats initially reduces choline acetyltransferase (ChAT) activity, which later rebounds, correlating with functional recovery and changes in nerve growth factor (NGF).

Area of Science:

  • Neuroscience
  • Spinal Cord Injury Research
  • Biochemistry

Background:

  • A graded spinal cord injury model in rats was previously established.
  • Mild contusive injury leads to initial severe functional deficits that improve over time.

Purpose of the Study:

  • To investigate changes in choline acetyltransferase (ChAT) activity and nerve growth factor-like immunoreactivity (NGF-LI) after mild contusive spinal cord injury in rats.
  • To explore the relationship between these biochemical changes and functional recovery.

Main Methods:

  • Utilized a mild contusive spinal cord injury model in rats.
  • Measured choline acetyltransferase (ChAT) activity at various time points post-injury.
  • Assessed nerve growth factor-like immunoreactivity (NGF-LI) using a two-site ELISA.

Related Experiment Videos

Main Results:

  • Mild spinal cord injury significantly decreased ChAT activity within the first week, with maximal reduction at the injury site.
  • ChAT activity rebounded over the next three weeks, correlating with partial functional recovery.
  • NGF-LI increased significantly after injury, peaking at 7 days, and then decreased as ChAT activity rebounded.

Conclusions:

  • Mild spinal cord injury impacts ChAT activity and NGF-LI levels.
  • The temporal dynamics of ChAT activity rebound are associated with functional recovery.
  • Further research is warranted to elucidate the role of NGF in promoting functional recovery after spinal cord injury.