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Brain corticotropin-releasing hormone increases arousal in stress
T Shibasaki1, N Yamauchi, M Hotta
1Department of Medicine, Tokyo Women's Medical College, Japan.
Brain Research
|July 19, 1991
Abstract:
The effect of restraint stress on pentobarbital-induced sleeping time was examined in rats. Restraint for 60 and 75 min significantly shortened pentobarbital-induced sleeping time. The shortening of sleeping time by restraint was completely reversed by intracerebroventricular (i.c.v.) administration of alpha-helical CRH(9-41), a corticotropin-releasing hormone (CRH) receptor antagonist. In conjunction with our previous finding that i.c.v. administration of CRH shortens pentobarbital-induced sleeping time, the results suggest that restraint stress increases arousal through brain CRH.