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Published on: August 15, 2025
Primary extracranial meningioma of the mandible
Adalberto Mosqueda-Taylor1, Hugo Domínguez-Malagon, Ana-Maria Cano-Valdez
1Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, México, DF. mosqueda@correo.xoc.uam.mx
Abstract:
Meningiomas are benign tumors of mesodermal origin that arise from arachnoid cell clusters that penetrate the dura to form arachnoid villi. These neoplasms represent one of the most common neoplasms developing within the central nervous system and are usually located at points of entry of vessels and nerves through the dura. Extracranial meningiomas (EM) comprise only 2% of all meningiomas, and only six cases of primary EM of the jawbones have been described to date. They may arise as an extension of intracranial meningiomas or as primary tumors and may be clinically indistinguishable from other benign tumours of the jaws, as they usually present as a well-delineated unencapsulated tumors. In this article a case of primary intramandibular primary EM that appeared as a well-defined osteolytic radiolucent lesion of the jaw is reported. The salient clinico-pathological features of this case is compared to those previously reported in the literature and differential diagnosis and therapeutic considerations are discussed.
Insights
This report details a rare case of primary extracranial meningioma (EM) in the jawbone, presenting as an osteolytic lesion. Further research is needed to understand these uncommon jawbone tumors.
Area of Science:
- Neurosurgery
- Oncology
- Oral and Maxillofacial Surgery
Background:
- Meningiomas are common central nervous system tumors of mesodermal origin.
- Extracranial meningiomas (EM) are rare, accounting for 2% of all meningiomas.
- Primary EM of the jawbones is exceptionally rare, with only six cases reported previously.
Observation:
- A case of a primary intramandibular extracranial meningioma is presented.
- The tumor appeared as a well-defined, osteolytic, radiolucent lesion in the jaw.
- Clinically, it was indistinguishable from other benign jaw tumors.
Findings:
- This case represents a unique instance of primary intramandibular EM.
- The clinico-pathological features were compared with previously reported cases.
- Differential diagnosis and therapeutic strategies for this rare condition were discussed.
Implications:
- Highlights the importance of considering rare diagnoses in jaw lesions.
- Contributes to the limited literature on primary extracranial meningiomas of the jaw.
- Informs clinical practice regarding the diagnosis and management of these unusual tumors.
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