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Updated: Jun 24, 2026

Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
Restoration of chemosensitivity by bortezomib: implications for refractory myeloma
Chor Sang Chim1, Yu Yan Hwang, Clara Pang
1Department of Medicine, Queen Mary Hospital, Hong Kong. jcschim@hku.hk
Background:
A 59-year-old woman presented to the emergency department with a left rib fracture and was diagnosed with IgA multiple myeloma. The patient underwent autologous bone-marrow transplantation, and 14 months later she developed obstructive jaundice.
Investigations:
Serum protein electrophoresis, contrast CT of thorax and abdomen, endoscopic retrograde cholangiopancreatography with endoscopic biopsy and pleural biopsy.
Diagnosis:
Extramedullary plasmacytomas at pancreatic head and pleura.
Management:
Salvage chemotherapy regimens including bortezomib plus steroid, alkylators plus steroid, bortezomib plus anthracycline and radiotherapy, and combined bortezomib, cyclophosphamide, melphalan and steroid therapy.
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