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Related Experiment Videos

Kindling-induced potentiation in the piriform cortex.

R J Racine1, K A Moore, C Evans

  • 1Department of Psychology, McMaster University, Hamilton, Ont., Canada.

Brain Research
|August 16, 1991
PubMed
Summary
This summary is machine-generated.

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Kindling, a process of repeated electrical stimulation, causes long-lasting potentiation in the piriform cortex. This study shows kindling-induced potentiation persists for at least three months, unlike long-term potentiation.

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Neuroplasticity

Background:

  • Kindling is a model for epilepsy development involving permanent increases in response strength after repeated stimulation.
  • Kindling-induced potentiation shares similarities with long-term potentiation (LTP) but can be longer-lasting.
  • The piriform cortex and olfactory bulb are highly susceptible to kindling.

Purpose of the Study:

  • To investigate the longevity of kindling-induced potentiation in the piriform cortex.
  • To examine changes in synaptic facilitation and inhibition following olfactory bulb kindling using paired pulse techniques.

Main Methods:

  • Olfactory bulb kindling was induced in experimental subjects.
  • Field potentials in the piriform cortex were measured following olfactory bulb stimulation.

Related Experiment Videos

  • Paired pulse stimulation was used to assess synaptic facilitation and inhibition.

    • Main Results:

    • Kindling induced a potentiation of the piriform field potential that persisted for at least 3 months with minimal decay.
    • Kindling led to a decrease in paired pulse facilitation, sometimes resulting in net depression.
    • Paired pulse measures returned to baseline levels over the 3-month observation period.

    Conclusions:

    • Kindling-induced potentiation in the piriform cortex is remarkably long-lasting.
    • Kindling appears to increase recurrent inhibition in the piriform cortex, though this effect may be transient.
    • The long duration of potentiation suggests significant, stable neural changes following kindling.