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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Nanomole-scale natural products discovery
1Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, MC0358, La Jolla, CA 92037, USA. tmolinski@ucsd.edu
Current Opinion in Drug Discovery & Development
|April 1, 2009
Summary
Advancements in nuclear magnetic resonance (NMR) spectroscopy enable natural product discovery from nanomole-scale samples. This review highlights spectroscopic developments and case studies for identifying rare compounds.
Area of Science:
- Natural Product Chemistry
- Analytical Chemistry
- Spectroscopy
Background:
- Natural product discovery relies heavily on spectroscopic techniques.
- Nuclear Magnetic Resonance (NMR) spectroscopy is crucial for structure elucidation.
- Recent advancements have significantly improved NMR sensitivity.
Purpose of the Study:
- To review the development of spectroscopic methods for natural product discovery.
- To present case studies on structure elucidation using minimal sample amounts.
- To explore future possibilities in natural product research.
Main Methods:
- Review of spectroscopic technique development, focusing on NMR.
- Analysis of case studies involving small-scale natural product analysis.
- Discussion of advancements in NMR probe technology (microprobe, microcoil, cryoprobe).
Main Results:
- NMR sensitivity has increased 20-fold in the last decade.
- The 'nanomole-scale' is now achievable for natural product exploration.
- Successful structure elucidation of natural products from minute quantities is demonstrated.
Conclusions:
- Modern spectroscopic techniques, especially NMR, have revolutionized natural product discovery.
- The ability to analyze trace amounts opens new avenues for exploring rare compounds.
- Future research will leverage current and emerging spectroscopic innovations.
