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Updated: Jun 24, 2026
06:54
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
Targeting TGFbeta-mediated processes in cancer
1Department of Biochemistry and Medical Biotechnologies, Federico II University, via Pansini 5, 80131 Naples, Italy. romano@dbbm.unina.it
Current Opinion in Drug Discovery & Development
|April 1, 2009
Summary
Transforming growth factor beta (TGFbeta) plays key roles in development and homeostasis. Aberrant TGFbeta signaling contributes to cancer, prompting the development of targeted therapies.
Area of Science:
- Oncology
- Molecular Biology
- Cell Signaling
Background:
- Transforming growth factor beta (TGFbeta) is a crucial cytokine regulating embryonic development and tissue homeostasis.
- TGFbeta signaling is vital for epithelial, neural, and immune system differentiation and function.
- Autocrine and paracrine TGFbeta-mediated processes are increasingly implicated in various cancers.
Purpose of the Study:
- To review the causes of TGFbeta malfunction in cancer.
- To present the rationale for targeting TGFbeta therapeutically in human neoplasia.
- To outline molecular strategies for modulating TGFbeta signaling in cancer treatment.
Main Methods:
- Literature review of studies on TGFbeta in cancer.
- Analysis of TGFbeta's role in different tumor types and stages.
- Examination of molecular mechanisms underlying TGFbeta dysregulation.
Main Results:
- TGFbeta malfunction is a significant factor in cancer development and progression.
- Targeting TGFbeta offers a promising therapeutic strategy for various human neoplasms.
- Understanding molecular pathways is key to developing effective TGFbeta-modulating therapies.
Conclusions:
- TGFbeta dysregulation contributes to oncogenesis.
- Therapeutic targeting of TGFbeta pathways holds potential for cancer treatment.
- Further research into molecular strategies is essential for successful clinical application.
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