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Related Experiment Video

Updated: Jun 24, 2026

A System for ex vivo Culturing of Embryonic Pancreas
10:51

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

Xenopus pancreas development.

Esther J Pearl1, Cassandra K Bilogan, Sandeep Mukhi

  • 1Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montréal, Montréal, QC Canada.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|April 1, 2009
PubMed
Summary
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The African clawed frog (Xenopus) is a valuable model for studying pancreas development. Research in Xenopus aids in understanding organogenesis and developing treatments for pancreatic diseases like diabetes and cancer.

Area of Science:

  • Developmental Biology
  • Comparative Organogenesis

Background:

  • Pancreatic diseases, including diabetes and cancer, necessitate a deeper understanding of pancreas development.
  • The African clawed frog (Xenopus) has emerged as a significant model organism in developmental biology.
  • Previous research highlights Xenopus's utility in studying early patterning and lineage specification during pancreas organogenesis.

Purpose of the Study:

  • To provide a comprehensive review of pancreas development in Xenopus.
  • To detail pancreas development from endoderm regional specification during gastrulation through metamorphosis.
  • To contextualize Xenopus research within the broader field of pancreas development studies.

Main Methods:

  • Review of existing literature on Xenopus pancreas development.

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In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors
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In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors

Published on: July 19, 2014

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Last Updated: Jun 24, 2026

A System for ex vivo Culturing of Embryonic Pancreas
10:51

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors
08:35

In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors

Published on: July 19, 2014

  • Focus on key developmental stages from gastrulation to metamorphosis.
  • Comparative analysis with other model organisms.

    • Main Results:

    • Xenopus facilitates the study of early endoderm patterning crucial for pancreas formation.
    • Lineage specification events in Xenopus contribute to understanding organogenesis.
    • The review consolidates knowledge on Xenopus pancreas development from early specification to mature organ formation.

    Conclusions:

    • Xenopus offers unique insights into pancreas organogenesis, aiding disease research.
    • This review serves as a guide for researchers new to Xenopus and those comparing models.
    • Understanding Xenopus pancreas development is vital for advancing treatments for pancreatic diseases.