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Irritable Bowel Syndrome

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

Inflammatory Bowel Disease I: Introduction

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

Irritable Bowel Syndrome III: Medical and Nursing Management

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 24, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

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Published on: May 31, 2024

[Postinfection irritable bowel syndrome].

A I Parfenov, I N Ruchkina, R I Ataullakhanov

Terapevticheskii Arkhiv

|April 2, 2009

Summary

This summary is machine-generated.

Post-infection irritable bowel syndrome (PICS) is characterized by gut infections, dysbiosis, and immune deficiencies. Treatment with intestinal antiseptics, probiotics, and immunomodulators achieved remission in most patients.

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Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

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Published on: September 21, 2015

Area of Science:

Gastroenterology
Immunology
Microbiology

Context:

Post-infectious irritable bowel syndrome (PICS) presents a complex challenge in gastroenterology.
Understanding the pathogenesis and diagnostic criteria for PICS is crucial for effective management.

Purpose:

To characterize the pathogenesis, clinicolaboratory criteria, and treatment of PICS.
To differentiate PICS from other forms of Irritable Bowel Syndrome (IBS).

Summary:

A study of 750 patients identified PICS in 79.9%, marked by diarrhea, abnormal fecal microflora, and immune system alterations.
Key findings include low phagocytic activity and attenuated cell-mediated and humoral immunity in PICS patients.
Etiotropic and pathogenetic treatments, including intestinal antiseptics, probiotics, and immunomodulators, led to sustained remission in 79.3% of patients.

Impact:

This research provides a comprehensive characterization of PICS, distinguishing it from IBS through specific biomarkers.
The study highlights the efficacy of a targeted therapeutic approach involving intestinal antiseptics, probiotics, and immunomodulators for PICS management.
Findings offer valuable insights for clinicians in diagnosing and treating PICS, improving patient outcomes and quality of life.