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Updated: Jun 24, 2026

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
Published on: August 26, 2021
Abstract:
The problem of the control of cardiac rhythm has been considered in terms of the general theory of the synchronization of relaxation systems. The main pathways of the control of cardiac rhythm have been determined: (1) control with regard for the features of synchronization of relaxation systems during the formation of the unified heart rhythm due to the acceleration of the slow diastole depolarization phase; (2) control by gradual integral increase in the duration of the slow diastole depolarization phase; (3) subsequent synchronization of the rhythm as a delay of the slow diastole depolarization phase. Possible applications of the mathematical simulation methods to study the mutual synchronization during the formation of the unified heart rhythm and synchronization for the effective control of the formed unified rhythm of the sinoatial node are considered.
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