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A comparative analysis of response to vs. ORS + gelatin tannate pediatric patients with acute diarrhea

J Esteban Carretero1, F Durbán Reguera, S López-Argüeta Alvarez

  • 1Department of Gastroenterology, Hospital Torrecárdenas, Almería, Spain. jcestebanc@saludalia.com

Revista Espanola De Enfermedades Digestivas
|April 2, 2009
PubMed

Insights

Adding gelatin tannate to oral rehydration salts (ORS) significantly reduced stool frequency in children with acute diarrhea. This treatment combination showed a greater stool decrease index compared to ORS alone.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Pharmacology

Background:

  • Acute diarrhea is a common pediatric illness, leading to dehydration and requiring effective management.
  • Oral rehydration salts (ORS) are a standard treatment, but additional agents may improve efficacy.

Purpose of the Study:

  • To evaluate the efficacy of ORS combined with gelatin tannate compared to ORS alone in treating acute diarrhea in children.
  • To assess the impact on stool frequency and other clinical parameters.

Main Methods:

  • A cohort study involving pediatric patients (3 months to 12 years) with acute diarrhea (≥3 liquid stools/day, <72h duration).
  • Patients received either ORS alone or ORS plus gelatin tannate.
  • Primary endpoint: number of stools at 12 hours; secondary: Stool Decrease Index (SDI), vomiting, dehydration, weight, and signs of peritonitis/sepsis.

Main Results:

  • The ORS + gelatin tannate group showed a significantly greater Stool Decrease Index (SDI) (-0.6023) compared to the ORS-only group (-0.1894) (p < 0.0001).
  • This corresponds to a 60% decrease in stools for the ORS + gelatin tannate group versus an 18% decrease for the ORS group.
  • No significant differences were observed in other clinical variables, though a trend towards improvement was noted.

Conclusions:

  • Gelatin tannate, when added to ORS, significantly reduces stool frequency in pediatric acute diarrhea.
  • The combination therapy demonstrates superior efficacy in decreasing stool output compared to ORS alone.
  • Gelatin tannate represents a promising adjunct therapy for managing acute diarrhea in children.
Abstract

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