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Updated: Jun 24, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
Recognition and management of hereditary colorectal cancer syndromes
1Service of Digestive Diseases, Unit of Prevention and High-risk Gastrointestinal Cancer Clinic, Clínica Universidad de Navarra, Pamplona, Spain. mherraizb@unav.es
Abstract:
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing helps diagnose affected individuals and allows identification of individuals at-risk. Colonoscopy and prophylactic colectomy decrease colorectal cancer incidence and overall mortality in patients with hereditary colon cancer. Extracolonic tumors are frequent in these syndromes, so specific surveillance strategies should be offered.
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