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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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Aurora kinase inhibitors in preclinical and clinical testing

Chun Hei Antonio Cheung1, Mohane Selvaraj Coumar, Hsing-Pang Hsieh

  • 1Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC.

Expert Opinion on Investigational Drugs
|April 2, 2009
PubMed
Abstract

Insights

Aurora kinase inhibitors are crucial for targeting mitotic errors and genomic instability in cancer. This review highlights 13 inhibitors in clinical trials, supporting their development for cancer therapy.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Drug Discovery

Background:

  • Mitosis is essential for cell division; errors can cause genomic instability.
  • Aurora kinases (A, B, C) are critical for mitosis, and their dysregulation is linked to cancer.
  • Targeting aurora kinases offers a potential molecular-based cancer therapy.

Purpose of the Study:

  • To review existing literature on aurora kinase inhibitors.
  • To assess their clinical and preclinical development status.

Main Methods:

  • Literature search conducted using PubMed, SciFinder, and clinicaltrials.gov.
  • Focused on aurora kinase inhibitors in cancer research.

Main Results:

  • Approximately 13 aurora kinase inhibitors are in Phase I/II clinical trials.
  • Numerous other inhibitors are undergoing preclinical testing.
  • Preclinical and clinical data are being evaluated for future development.

Conclusions:

  • Aurora kinase inhibitors show promise for cancer treatment.
  • Further development is warranted, potentially in combination therapies.
  • Targeting aurora kinase is a key strategy for combating tumorigenesis.

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